Then there is the question of open source. Most grants require the work to be open source at the outset.Perfectly fine, but negating the possibility of an initial commercial advantage. Many are perfectly happy to give everything away for a few zaps, but others want to invest first for an advantage before giving away.
Discussion
This will not be feasible, soon, as reverse-engineering automation will make everything de facto open-source. We just have to adjust to FOSS.