Here are two observations I've made while operating this way:

It's absolutely essential to back up private keys. If copies exist in both a browser and a bunker, it's highly unlikely both would fail simultaneously. However, if a key only exists in one location, it's extremely vulnerable to device failure (a lesson learned the hard way).

Surprisingly, many Nostr applications don't support NIP-46. What's even rarer is for clients to support generating tokens and passing them to a bunker. This is largely because nostr-tools primarily supports the bunker generating tokens and sending them to the client.