Unless you just use JS web components and ditch the retard skinny jeans man bun transpilation toolchain that has always sucked donkey dicks
Discussion
It's not as perfomant but python micro frameworks for web apps is much less complex than any JavaScript framework.
The UI is all JS no matter what. Best to use web standards and avoid all frameworks and build tools. We don't need them.
That depends on what general purpose language you want to use for your backend though. Go is much more perfomant than JS, it's strongly typed and compiled. Development is much better than JS or Python