Cons of Methylthioninium Chloride as synthetic Supplement

* Dose Sensitivity – Benefits are seen at low doses, while high doses can be neurotoxic and oxidative.

* Serotonin Syndrome Risk – Can interact with SSRIs, MAOIs, and other serotonergic drugs, potentially causing dangerous serotonin syndrome.

* Urine & Skin Discoloration – Turns urine blue/green and can stain skin, making it noticeable in some users.

* Potential Toxicity at High Doses – Excessive use can lead to oxidative stress, hemolysis (especially in people with G6PD deficiency), and other toxic effects.

* Limited Human Studies for Cognitive Enhancement – While promising, most cognitive benefits are based on animal studies and limited human trials.

* Contraindications for Certain Medical Conditions – Not recommended for people with G6PD deficiency, severe kidney issues, or those taking certain medications.

*Gastrointestinal Issues – Some users report nausea, stomach discomfort, or diarrhea.

* May Affect Blood Pressure – Can cause mild vasoconstriction, which may impact blood pressure regulation in sensitive individuals.