I think a big issue is a lack of visibility. It's hard to know which clients are being used, how long it takes for your notes to be seen, if they're seen at all and by what % of your followers. Haven't looked at the protocols for a while but this is why to advocate for things like user agent strings, opt-in read receipts, etc.
I don't know where to post this but since nostr:npub180cvv07tjdrrgpa0j7j7tmnyl2yr6yr7l8j4s3evf6u64th6gkwsyjh6w6 posted on how nostr was big relays dependant I tried using only small relays but I'm having a lot of issues :
- profile info missing
- missing notes (some of my follows notes were completely out of my feed)
- big latence to fetch data (notes appear suddenly in my feed or profile info updated after at least 5-10 seconds)
I don't know who could be interested in that feedback. Feel free to tag people in comments.
Here's an example on #bitcoin (I use amethyst)
And on nostr chats it is even worse :
https://video.nostr.build/87105ea5ebd82299d8905e9e69e058c97e2e52cc42af5c2947c718b5746d1fd6.mp4 https://video.nostr.build/8bef2f50a2e957a79d9db2adc32ac7a8d3a9cdde52e3a9fcd1ec490ea74ec786.mp4
The relays I use :

#nostr
#nostrdev
#amethyst
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