Peptide use is dangerous as we don't know which tissues are being changed. Taking peptides like Ozempic is like driving the Autobahn with no lights, wearing blue-blocking glasses at 01:00 in the morning. Some peptides can be deadly for some people. The precaution principle
Dr. Jack Kruse: "The use of peptides is dangerous. You should stay as far away from it as you can because we don't know enough. [...] Mitochondria actually make about 1,200 peptides that actually alter physiological redox functioning. And when you don't understand how the peptides work totally, and you start to use them, you have a problem.
"Let's use the one peptide now that kind of everybody knows about, which is Ozempic. If you listen to the Ozempic commercials, they'll always tell you if you have MEN-1 or -2, you shouldn't use Ozempic. If you're a type 1 diabetic, you should not use Ozempic, but if you're a type 2 diabetic, you should use it. Immediately, what that should cause you to realize is, why is it that certain people can't use certain peptides? OK, that's the question that should come up, but that's not the question that most people ask themselves. It turns out for people that have different Fitzpatrick scores, different SNIPS, different SAPs, different haplotypes, guess what? Certain peptides can be deadly. And it turns out that Ozempic can be a real problem. And this is the reason why it's associated with like MEN syndromes.
"Most people don't know just how Ozempic works, it's a GLP1 drug or peptide, is that it affects exogenous thyroid tissue that's elsewhere in the body. Most people have the belief that doctors get in medical school that your thyroid is only in your thyroid gland in your neck. It turns out, especially humans, further you go on the evolutionary tree, we tend to have extranodal thyroid gland in other places. It turns out that's where the Ozempic peptide can cause some funny, how shall we say, signaling, physiologic signaling, to lead to medical comorbidities, and one of those things actually can be a cancer syndrome. That's what MEN syndrome is.
"When you hear the story between type 1 and type 2 diabetics, I think most people who are not science-based know that there's a difference between type 1 and type 2. But the difference that they believe comes down to the production or non-production of insulin. Well, it turns out that's not the only issue. The other issue is that type 1 diabetics are created radically different than type 2 diabetics, and type 1 diabetics have different phenotypes than type 2s. So it should raise the question, why is Ozempic a problem for type 1 diabetics? And it has a lot to do with the thermodynamics of the story.
"My basic thesis has always been you use the precaution principle when you're at the edge of a science that you really don't know the answer. And when it comes to peptides, we don't know the answer.
[...]
"So fundamentally, when you take peptides, what effectively are you doing? You are actually changing the charge density of different tissues in your body, and you don't know what tissues are being changed. Therefore this is kind of like driving the Autobahn with no lights, wearing blue-blocking glasses at 01:00 in the morning. Makes no fucking sense at all."
Dr. Jack Kruse with Steve on The Paleo Cyborg Podcast @ 01:16–05:31 & 07:39–08:06 (posted 2023-12-23) https://www.ivoox.com/en/11-dr-jack-kruse-audios-mp3_rf_121655353_1.html