I have about an ergonomic a setup as you can imagine

And right hand still needs a break from using the mouse

So i'm experimenting with shifting hands

Ever switched your mouse hand to non-dominant?

Thoughts?

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Show me your mouse, and setup

Standing desk too

That keyboard is causing me pain just by looking at it 😅

Check/try wrist foam wrests - these exist both for keyboard, and for mouse

https://www.logitech.com/en-us/products/keyboards/mx-palm-rest.956-000001.html

Personally these work well for me:

mini keyboards (no numpad) logitech mx keys mini

Near-vertical mouse (looks like you have one) Logitech mx vertical ergonomic mouse

Yes, left side is great because numpad isn't in the way. I switch back and forth every couple weeks