I'd add sugar as well, though I see many people talk about 'dose make the poison'

How many people are calculating their amount of sugar, caffeine, nicotine, or alcohol use on a given day? Are they optimizing for minimal inflammation?

The driving factor for the use is pleasure, and usually in a mixed ratio optimized for taste. Studies talked about in a book that I think is called 'Salt, Sugar, Fat', they inform us on a human tendency to not feel satisfied when the right ratios are present (e.g. chocolate bars, candy, potato chips, fast food, etc.)

I have alcohol and caffeine from time to time but I drink whiskey sodas and black coffee. Its not just for utilitarian purposes, my tolerance for sugary food and drink has waned from being on a low/no carb way of eating for quite some time.

Now agreeing that 'the dose make the poison' its also important to have a multivariable analysis of the situation. What is the historical data on these drugs and their user base? How long have they been in use? What is the cultural environment around their usage?

Believing the argument being made is a form of hormesis on a dietary level is helpful, lifestyle hormesis is great, but dietary hormesis may not be the best route to go in the long run.

The likelihood for someone to take an extremely long ice baths or sauna sessions, and keep on doing it for a sustainable time period, is low. I'd never tell someone to not lift weights if they've never picked up a thing in their life. I'd be comfortable to say, "Hey, if you haven't had [name the poison], best not to make regular use of it if you want to live an optimally healthy life."

There may be benefits to having caffeine here and there and the same goes for alcohol or nicotine, but the act is futile without acknowledging that prolonged use is detrimental to overall health.

Alcohol, caffeine, nicotine, and sugar are not just poisons due to their inflammation and other health impact factors, they may be the most detrimental due to their acceptability and slow burn destruction of the human body over a lifetime.