if you're comparing immunologists to bitcoin core devs you're going to have a bad time. biology is a very unexplored in terms of its systems and effects of new drugs on these systems.

bitcoin core is very much understood and has very well established domain experts.

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Dynamic complex systems vs deterministic rules based systems apples to oranges.

I'm ignorant on the subject, why knots, why core, no idea. But after your post I downloaded and installed knots. Guess I'm just an ignorant emotional idiot after all... Good to know for sure.