There is not a lot of privacy if you use SimpleX or Signal with the company's default servers. The servers can see a lot of the metadata.
That is why I fundamentally think Nostr is better for DMs than anything else. The choice of the DM inbox relay here is at the forefront of the user experience.
And if you don't trust any server, you can always and easily do P2P DMs in nostr such that the messages never reach any relay.