I copied this from a telegram group.
I don’t think I should mention who posted it or the name of the group, but I wanted a permanent record of this information so I’m making it a note:
🧬 Thymosin Beta-4 (TB4)
📄 CAS Number: 77591-33-4
⚖️ Molecular Weight: 4963.55 Da
🧪 Amino Acid Sequence:
SDKPDMAEXEKFDKSKLKKTETQEKNPLPSKEXXEQEKQAGES
Thymosin Beta-4 (TB4) is a 43-amino acid peptide naturally found in a variety of tissues. Much of TB4's biological activity comes from its ability to sequester actin and regulate its polymerization, which plays a key role in tissue repair and regeneration. The complete sequence is important for wound healing, tissue regeneration, and anti-inflammatory effects.
⏳ Half-life:
🕒 Very short — estimated to be minutes to ~2 hours in vivo due to rapid degradation.
✅ Key Benefits of TB4:
🩹 Promotes tissue and wound healing
🩸 Stimulates angiogenesis
⚙️ Regulates actin polymerization
🔥 Reduces inflammation
🧠 Provides neuroprotection
💪 Speeds up muscle recovery
🛡️ Supports immune modulation
🧫 Protects tissues under stress conditions
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💉 TB-500 (TB4 Fragment 17–23, Acetylated)
📄 CAS Number: 885340-08-9
⚖️ Molecular Weight: 889 Da
🧪 Amino Acid Sequence: ac-LKKTETQ
TB-500 is a synthetic fragment corresponding to amino acids 17–23 of the TB4 sequence. It is chemically identical to Fequesetide, with the addition of an acetyl group, which enhances stability and prolongs its duration of action.
⏳ Half-life:
🕒 ~2–3 days after subcutaneous injection (thanks to acetylation and improved resistance to degradation).
✅ Key Benefits of TB-500:
💪 Enhances musculoskeletal repair
🔥 Reduces inflammation
⏱️ Speeds up injury recovery
🧵 Promotes tissue regeneration
🚀 Boosts cell migration
🧊 Provides longer-lasting effects
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🧬 Fequesetide (TB4 Fragment 17–23, Non-Acetylated)
📄 CAS Number: 476014-70-7
⚖️ Molecular Weight: 846.97 Da
🧪 Amino Acid Sequence: LKKTETQ
Fequesetide is the non-acetylated version of TB-500. Though it shares the same amino acid sequence, its lack of acetylation makes it significantly less stable, and thus it’s mainly used in in vitro or research-focused settings.
⏳ Half-life:
🕒 Minutes to <1 hour, very short due to rapid enzymatic degradation.
✅ Key Benefits of Fequesetide:
🩸 Stimulates angiogenesis
❤️ Enhances blood flow
🔬 Supports vascular-focused research
📉 Low stability limits broader applications
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🫀 TB4 Fragment 1–4 Goralatide (SDKP)
📄 CAS Number: 120081-14-3
⚖️ Molecular Weight: 487.5 Da
🧪 Amino Acid Sequence: SDKP
SDKP is a naturally occurring bioactive tetrapeptide derived from TB4, known for its cardiovascular protective and anti-fibrotic properties. It plays a key role in controlling fibrosis, inflammation, and organ remodeling.
⏳ Half-life:
🕒 Very short, around 4–6 minutes in plasma — yet bioactive at very low concentrations.
✅ Key Benefits of SDKP:
❤️ Provides cardioprotection
🫁 Reduces fibrosis in organs (heart, lungs, kidneys)
🧵 Limits collagen accumulation
🔥 Powerful anti-inflammatory effects
🛡️ Reduces monocyte infiltration
🧠 Offers neuroprotection
🔧 Supports cardiovascular repair