It depends what. Electronics is not a problem at all - the largest Czech seller Alza (local "Amazon") accepts crypto, as does my favorite growing store. Alternatively, there is Amazon.de, where you can buy almost everything with a bitrefill coupon.

Groceries are probably the biggest problem, but even that can be solved through bitrefill, where you can buy a Kaufland coupon. And in restaurants there is sometimes Qerko Pay with Bitcoin support.

It is difficult to avoid a fiat, but in the Czechia it is relatively possible without much discomfort. At worst there is veksl (p2p cash-crypto) and cash :)