You would of course, run tests on what you created to see if it's harmful or not

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Familiar with Roundup? It's a highly toxic chemical that kills nearly anything it touches. Crops were "bioengineered" to be tolerant to roundup. Farmland was then saturated with Roundup, killing only the undesirable plants (weeds).

"Testing" the bioengineered crops would have revealed no problematic effects to the plant. But it turns out human consumption of Roundup is VERY harmful.... nature would have never produced a plant immune to Roundup. Gene editing did. Unfortunately the second/third order effects became apparent only after the practice was already mainstream.... this is a large contributor to America's food supply being toxic

Interesting case, but this is unrelated to the gene editing itself. The problem is Roundup. This is a problem of capitalist system which does not really care who gets cancer, or in the case of private, for profit healthcare, even incentivizes more cancer - because a looooot of profit can be made curing it.

Sure. In this case. I'm just pointing out the problem with unforeseen consequences. You are implying these ppl are good at anticipating consequences. I am suggesting they are abysmal at it. Therefore there should be no tinkering with the source code

Nature is the only proofreader I even marginally trust.