No. But, if it were more lopsided could affect adoption. Let's say we had all of the same miner and node counts and one wallet held 99% of the supply and 1% the rest. Bitcoin's network would be just as decentralized as it is now. However, Metcalfe's law would likely kick the project into the dust bin of history due to lack of adoption. I think we're safely on the rising adoption curve now.