Dr. Jack Kruse: "Nitric oxide is the paramagnetic switch that flips us from choices in metabolism. You know what that means? That means that all metabolism happens spontaneously and Archimedes lever is the light that turns it on.
"Then you got to ask yourself a big question. Are we talking about light that comes from our star or are we talking about light that may come from inside of us? Now remember I told you the story about Lynn Margulis and her husband, that a G-class star makes more UV light. You may be surprised to know that this UV light story ties to NO. You just said it: in your skin. You know these parts, but what you don't understand is how it fits in the quantum design of a cell. And what happens when this UV light shows up on Earth, oxygen levels spike further, things are selected out in our membranes, especially in eukaryotes.
"That's where DHA from the seas gets incorporated. DHA, meaning fish oil, in the marine food chain, is really, really important. Why? Because for us to use it, meaning eukaryotes, it has to be in a specific position. It comes in three different positions, SN1, SN2 and SN3. […] The glycerol backbone of lipids has a carbon chain, and the SN1, SN2 and SN3 position are which carbon it's linked to. It turns out for eukaryotes like us, meaning primates, it works and it's only incorporated into the brain and into the leptin-melanocortin pathway when it's in the SN2 position.
"That's the reason why people need to eat fish and not take fish oil, because fish oil tends to be in SN1 and SN3. We need the fish to do the job for us. That's the other reason you don't want to use algal oil as well.
"What's the quantum reason that this is important? It turns out the SN2 position is very planar. It looks just like a copper wire. It has pi electrons on the top and bottom, which means that it works really well. Where is the most common place, what's the place with the highest density of SN2 DHA in the human body? It's in the central retinal pathways that connects your retina to that leptin receptor that Nick's been wanting to chomp at and get to."
Nick Jikomes: "Basically one way of saying some of what you just said is that we talk about fish oil, we talk about omega-3 fatty acids, we talk about DHA. From a biochemical perspective, you might say, 'Well, the DHA that's in my fish oil is the same that's in the fish I could have eaten.' But it's not. There's a physical difference in some of the structure."
Dr. Jack Kruse: "Right. And that's the keyword. The word that you're going to keep coming back to when you realize how much you have to unlearn is biochemistry taught you no biophysics."
Dr. Jack Kruse with Nick Jikomes @ 21:38–24:44 (posted 2025-04-09) https://youtu.be/67sLlXeMg2I&t=1298