Ladybugs are aphid eaters, a beneficial insect that you don't want to kill. not sure what's munching there, but a tablespoon of cayenne powder dissolved in a gallon of water with a squirt of dish soap, helps repel most munchers.

the powdery mildew can be treated with a sour milk mixed 50:50 with water. spray leaves of plants, underside too, water in as well, powdery mildew lives in the soil. both should be applied for several days until remedied. reapply occasionally.