Rule of thumb: Stick with poisons that people have been consuming for millennia, and avoid poisons of the 20th century. Enjoy your wine, coffee, and cigars.

Another rule of thumb: If you do one or two multi-day water fasts per year, you don't have to worry as much anymore about having the oPtiMaL hEaLThy diEt.

Anything beyond these rules is just pointless overoptimization; too much effort for no or hardly any gain; not a smart way to live life.