Confounders can make it difficult to determine the true relationship between the exposure and the outcome, because they can create the semblance of a more direct association that is not actually present.

https://www.researchgate.net/post/Moderated_mediation_with_two_independent_variables

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Discussion

There are two main types of measures of association: crude and adjusted. Crude measures of association are based on the raw data and do not take into account any confounding factors.

⛀ Boston University School of Public Health

https://sphweb.bumc.bu.edu/otlt/mph-modules/bs/bs704-ep713_confounding-em/bs704-ep713_confounding-em_print.html

⛀ Effect Modification Flashcards

https://quizlet.com/412490992/effect-modification-flash-cards/

Adjusted measures of association can give a more accurate estimate of the true relationship between the exposure and the outcome, because they take into account the effect of confounders by statistically controlling for them.

https://www.researchgate.net/figure/Crude-and-adjusted-measures-of-association-between-suspected-risk-factors-and-MDD_fig1_330219624