It takes up space, so node runners need to buy bigger hard drives to fit the blockchain on their nodes
Discussion
Storage is cheap. People were buying racks full of drives to mine stupid Chia, but few extra gigs of spam is a problem? This is exactly what I don't get. Again just a gut feeling.
Spam in OP_RETURNs can *decrease* the load on nodes, as the OP_RETURN data can be discarded ('pruned') by the nodes.
The best block, from a storage point of view, is filled with just one transaction that has a huge OP_RETURN taking up the entire megabyte.
(Even better is if the transaction takes many UTXOs as input, and has just a few outputs. But that's a slightly different issue)