the danger of proton pump inhibitors (ppi):

PPI forms a covalent bond with your proton pumps and inhibit them until degenerated 72hra later.

Your stomach pH goes from a highly acidic 1.5–2.0 to above 4.0 for most of the day

G-cells in your stomach produce gastrin to produce more acid, but since the pumps are disabled, the stomach can’t restore normal acid levels.

Stomach acid is required to cleave B12 from the proteins and with high pH the B12 won't get absorbed.

Also magnesium and calcium and zinc absorption is affected.

Stomach pH plays a role in converting non-heme iron (Fe3+) to the more absorbable ferrous form (Fe2+) which can't happen effectively at high pH

Pepsinogen the inactive precursor to pepsin requires a low pH in order to break down protein so protein absorption is affected.

Bacteria from your mouth and other areas can now colonize the upper GI tract since their growth is no longer inhibited by low pH

Stomach acid inactivates C. diff spores, and PPI users have a higher risk of C. diff infection because more spores can survive to the intestines.

Long-term PPI use is consistently associated with increased risk of hip and other bone fractures due to the mineral absorption issues.