I've encountered the concern before and it applies to onchain activity. Lightning transactions would be largely unaffected by the mining game theory at play in MEV.

Using Bitcoin for this purpose can't be stopped in the same way as arbitrary data storage. Consequently, we should embrace reality that Bitcoin is a neutral value transfer system.

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They can mess with channel open/closes though

https://xcancel.com/BobMcElrath/status/1928230514181189791#m