I don't. Last time I tried was 5 ish years ago and it didn't work, it did nothing. Now I'm simply less interested in the feeling of high, but I am very interested in what I might learn from ayahuasca or dmt - but at the same time, I think it has to be treated with reverence and be infrequent. In a few years, I might feel like I've learned enough to benefit from it.