I can validate that. I use Graphene, and Pokey worked the first time. I switched profiles and I've not been able to get it to work since, even though it says it's running. I've even uninstalled/reinstalled everything (Pokey, Zapstore, Amethyst), it seems I completely broke it. 😑
Discussion
Check your relay list next time. It should get fixed if you just stop and start the service. The bad news is that notifications before restart won't appear again.