Only if you'd get rid of the swamp that's DC, I'm pretty sure they won't just roll over and die.
Some people (Tim Pool for example) have predicted a civil war in the US. I don't think that will happen. I think it is much more likely that people will vote with their feet and separate into two distinct cultures, akin to cell division. A lot of the early-movers have alreay moved.
Consider this situation: https://twitter.com/elonmusk/status/1700297475628871719
Due to this law, right-wing late-movers who really don't want to leave California are now rather forced to leave or else they will lose their children.
The US will split. I hope it splits peacefully.
Discussion
That is the biggest hurdle. It has to be done by the states. The federal government will not like it though. Last time states tried to leave, there was a war.