yeah... it's mostly related to kidney disease, i think, and the biggest part of the damage that set me back this far was actually artificial sweeteners

there is a lot of evidence hinting at the idea that especially acesulfame-k is quite nephrotoxic, but the others to some extent as well

i was just noticing, also, a juice drink i got that has stevia as its sweetener, when i added some potassium chloride and sea salt, the flavor reminded me a lot of dutch salty liquorice, and i realised that stevia's sweetness is probably due to some similar glycoside type chemical in it that is like what's in liquorice - and i believe that too much of that stuff can do some bad things to your organs and stuff as well, but a little is ok

and here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962506/

the word "hypokalemia" appears as a symptom of excess liquorice consumption

it's probably related to a whole thing that is related to the taste of sweet and the chemical properties of sweet things

like, another sweet substance is dichloromethane... which is very hepa-and nephrotoxic, and interestingly also, magnesium is quite sweet, to the point where it is common parlance to talk about magnesium/calcium additives for soil being "sweeteners" and that it is something related to being opposite to sour, though that's not quite correct because bitter is the main flavor of alkali