Too much deuterium overwhelms the microbiome, leading to chronic disease

Cameron Borg: "So presumably there's a limit of deuterium to hydrogen that the body is capable of satisfactorily dealing with as far as keeping the mitochondria relatively deuterium free. Is the general idea that when that deuterium level reaches a certain point where the gating capacity is no longer able to do what it's supposed to do and keep deuterium out, this is what initiates disease? Or is it sort of the other way around, or potentially both, where this gating, perhaps even through the microbiome, this gating capacity is damaged, which then leads whatever deuterium is there to enter. Is it both scenarios are true?"

László Boros, MD: "Yeah, it's practically as long as you keep your deuterium low in your food and your consumables, what you consume, your microbiome is able to discriminate sufficient deuterium, meaning that you not going to have much deuterium in your circulation. Not as much as if your microbiome is damaged, you eat high-deuterium processed food, then your body cells have to, through glycolysis and the Warburg phenotype, have to start dealing with the excess deuterium and that's when chronic disease develops. That's what we call chronic diseases because they develop slowly without early symptoms. And then when it comes, they're hard to reverse, meaning that then those are practically indicating like permanent damage to this energy-producing combustion system. You cannot exhaust all the carbon source or carbon dioxide that is necessary for water production and ATP synthesis, but there's going to be like alternative shift and bypasses in metabolism, single carbon cycle, lactate production, and you name it.

"It's practically just a catch-22. Once you start messing with your ATP synthase production, energy production is because high-deuterium food consumption and there's a leaky gut that is kind of part of this damage to your microbiome and your epithelial cells. Then your body cells have to deal with deuterium, higher deuterium, and like they have to use glycolysis more intensely. Those triophosphate and hexose phosphate isomerase reactions that actually produce water from and during glycolysis to get rid of deuterium and try to replace those with low-deuterium matrix water derived protons that are not deuterium depleted any longer. So it's really then you are kind of in a kind of a vicious cycle of when biochemist concerned. And it's very hard to change after all. But you know there's always time to change, meaning that there's always way of starting, and there's always room for improvement, and so it's never late to start."

László Boros, MD with Cameron Borg @ 01:13:39–01:17:05 (posted 2025-09-23) https://youtu.be/DmuO5uFuAcE&t=4419