It's usually a matter of some clients only supporting NIP-04, which all clients should have burned on the trash-heap by now, and other clients rightly defaulting to NIP-17.
Though, to be fair, I believe nostr:nprofile1qqs8eseg5zxak2hal8umuaa7laxgxjyll9uhyxp86c522shn9gj8crspz9mhxue69uhkummnw3ezuamfdejj7qgjwaehxw309ahx7um5wgerztnrdakj7qgkwaehxw309a3x2an09ehx7um5wgcjucm0d5hsvlnggv discovered some clients that have NIP-17 DMs that weren't being received by other clients that also have NIP-17 DMs.
Did you ever get to the bottom of what was going on with that nostr:nprofile1qqs8eseg5zxak2hal8umuaa7laxgxjyll9uhyxp86c522shn9gj8crspz9mhxue69uhkummnw3ezuamfdejj7qgjwaehxw309ahx7um5wgerztnrdakj7qgkwaehxw309a3x2an09ehx7um5wgcjucm0d5hsvlnggv?