I'd start with mapping all IPs of all relays of nostr. also run a few free and paid ones myself as NSA.

Then, after a few weeks, you know all the characteristics.

Then I'de start to blast the network with bad actor relays and users, also making it hard to use with spam and garbage data.

After a while, I'd even go as far as have coders submit NIP proposals that have all "good" increments, but after a while (when put together) put more strain on the relays.

But in the end, I'd generally try a poison-the-well tactict.