Also consider the cost to verify lab science. Its easy to verify stuff in software. but is insanely expensive to verify a lot in some sectors of material sci/eng, biochem/biophys. Throwing up a lab independent of who is funding it is next to impossible for the avg citizen. Plus one can't control the raw materials in the same way
Discussion
This is a major crux of the problem, affording the equipment that standardizes the process. One could even make an argument that there is emphasis on requiring these machines to already make reproducibility difficult. Then you throw into the mix the incentives against reproducing in favor for novel research (you're not going to get funding to reproduce other's work), and the bias against publishing negative results.
100%
Peer Review has created a back scratching culture. those who speak about it often get punished for it
https://www.youtube.com/watch?v=U5sRYsMjiAQ
https://podcastnotes.org/portal-with-eric-weinstein/bret-eric-weinstein-portal-lab-mice-telomeres/
CDC/FDA/Big Pharma/NIH/Grant funded research all in bed with each other. You wanna keep your job in research? bend the knee. Unless you are independently wealthy and go fund your own thing, and they'll probably try to murder you along the way.
