Oh! Yes, Nostrudel supports this newer concept too and has a lot of options. I believe you can choose defaults or popular relays. nostr:nprofile1qqszv6q4uryjzr06xfxxew34wwc5hmjfmfpqn229d72gfegsdn2q3fgpr3mhxue69uhhxct5v4kxc6t5v5hxs7njvscngwfwvdhk6tcpzfmhxue69uhkummnw3e82efwvdhk6tcpz4mhxue69uhhyetvv9ujuerpd46hxtnfduhsk7wj75

As for running a relay, you'll need to ask yourself what kind run. Will it be a private relay or a public relay? Let me see if I can find some guides.