Yes. It should work with any software wallet which supports your seed phrase (most probably support the BIP-39 seed you’ll likely have generated)

I personally would also recommend 2 of 3 multisig, as you wouldn’t even have to worry about this potential issue. 2 of 2 just seems like having to keep track of double the seeds and double the hardware wallets, for very marginal security benefits.

Remember, you’re much more likely to lose your own keys then you are to have them stolen or hacked.