I did a dive on this a few days ago
Hopelessness is a lot more dangerous than any one could ever imagine. If you want me to go more into the biology and studies happy to discuss. But for now:
This may help:
https://youtu.be/2rJvWLN8rtE?si=3vV4LmffPzBG92kQ
Yes, please don't go to "despondent"
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What’s despondent?
It's "too hard" on the "mind control, not good feelings"