I see only a couple major options for businesses:

1) you design a system that falls outside of regulation,

2) you build within regulations, or

3) you manage the risk of not following regulations.

Realistically, most early stage companies will do a hybrid of 2&3 because it's nearly impossible to even know all the applicable rules, so most focus will go to the most consequential laws.

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I agree!

Or you make things open-source, so your work never will disappear.

Although this does not circumvent getting out of business. And I guess your aim with this list was to stay in business, not to make something worthwhile.

But at the end, the easiest way to keep your business alive is abiding by the rules. But this tie your hands in many ways that decreases innovation.

So at the end, everything boils down to personal preference.

4) you LOCATE a system so it falls outside of regulation

the US keeps moving the target in a man-made smoke screen