We don't really have an opinion on it, it's designed for GrapheneOS users so it should work. I've not heard of any reported issues myself.

In the future profiles may have their own localhost network access isolated with a toggle, which would stop it working if you enabled it, but this is a minor thing and not really being looked at as a priority.

Private Spaces (a secondary profile in the same environment as the current user) can let you share files between them via share dialogs without needing an app.