the benefits show up at between 0.5 and 4.0 mg per kilogram of bodyweight. To match the test data at the low end, a 200lb man would need to take 45mg, or around 2.5 droppers full of 1% solution. Above 15mg per kilogram of bodyweight, and the benefits start to reverse and will damage your mitochondria.
i started by taking .5mg per kilo a couple months ago, 4 days on 3 days off. the effects have been life changing.