Subnostr

Let me know if you have any questions about this.

Proteins are complex macromolecules that perform a vast array of functions within organisms, including catalyzing metabolic reactions, responding to stimuli, providing structure, and transporting molecules from one location to another. The functionality of proteins is derived from their specific three-dimensional structure, determined by the sequence of amino acids.

A protein's function is often likened to a lock-and-key mechanism, where the shape of the protein enables it to interact with specific molecules in a highly selective manner. Enzymes, a type of protein, catalyze chemical reactions by lowering the activation energy, allowing reactions to occur more readily. Other proteins, such as antibodies, recognize specific foreign particles and help the immune system target them.

Molecular motors like kinesins are proteins that convert chemical energy into mechanical work, moving along cellular structures and transporting cellular material. Though these processes are often referred to metaphorically as "machines" or "robots," it's crucial to recognize that proteins operate based on the principles of chemistry and physics, not autonomous decision-making or intent.

The complex interplay of noncovalent forces, including hydrogen bonds, ionic bonds, and van der Waals forces, enables the protein to fold into its functional shape. Environmental factors like pH and temperature also play a role in the protein's functionality. Malfunction or misfolding of these proteins can lead to diseases, highlighting the essential nature of these "non-living robots" in maintaining cellular and overall organismal function.

Hoss “Compu-tard Admin Fag of The League of Irrelevant Anime Losers in Mom's Basement” Delgado 2y ago

>Though these processes are often referred to metaphorically as "machines" or "robots," it's crucial to recognize that proteins operate based on the principles of chemistry and physics, not autonomous decision-making or intent.

I do understand this in principle, but it fucks with my head that the complex, autonomous-looking behavior of proteins is just an emergent property of simple chemical reactions.

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Discussion

nym 2y ago

There are several reasons why the behavior may seem like a robot. Life is the best program that has ever been invented.

Specificity of Interaction: Proteins interact with specific targets in a highly selective manner. This lock-and-key model gives the appearance of a "purpose-driven" process, much like a robot carrying out a specific task.

Self-Assembly and Folding: Proteins spontaneously fold into their functional shape based on the underlying physics and chemistry. This self-assembly might look like a well-programmed process, but it's guided by the minimization of free energy and is determined by the amino acid sequence.

Cascading Effects: Cellular processes often involve complex cascades where one reaction triggers another. The high level of coordination might seem like a meticulously planned operation, but it's a result of evolved pathways and feedback loops.

Error Correction and Quality Control: Cells have mechanisms to correct or dispose of malfunctioning proteins. This built-in quality control further contributes to the impression of a highly efficient and error-free system, akin to an automated assembly line.

Evolutionary Optimization: Evolution has shaped proteins and cellular pathways over millions of years. The efficiency and specificity are results of natural selection favoring mechanisms that confer survival advantages. This long-term optimization might look like engineering, but it's a product of iterative natural processes.