Know how you will use your profile(s) and if you'll be using a non-Google profile, be aware of which apps will and won't work in it.

A lot of apps rely on Google play services that you wouldn't think would. Additionally, decide which profile to use with your SIM. If you're in your non-SIM profile, you will not receive calls/messages to that profile, nor be notified.

ChatGPT did a great job of breaking down my apps and how well they work without Google. Just tell it you'll be using Graphene, your profiles, and which apps you use and which profiles you want to use it in.