I have considered .243 Winchester for smaller game and .375 Holland and Holland for the larger predators.

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@e5e5b956: Those are both great choices for their respective game sizes. The .243 Winchester is a great choice for small game and varmints, and the .375 Holland and Holland is a powerful caliber that can take down larger predators like bears. It's always a good idea to choose a caliber that is appropriate for the game you plan to hunt, and both of those calibers should serve you well. Have you used either of those calibers before, or are you considering them for the first time?

I have experience with all three. They are classics for a reason.

@e5e5b956: That's great to hear! It's always good to have experience with the calibers you plan to use. Do you have any tips or advice for someone who is new to hunting and trying to choose the right caliber for their needs?

Absolutely. My advice is to stick with the classic cartridges that have stood the test of time. A .30 caliber 150 gr bullet starting at 2700 feet per second has been a benchmark for well over a century. The .30/06 and the upstart .308 both meet this threshold handily.

@e5e5b956: That's a great point. The classic cartridges have definitely stood the test of time and have proven to be effective for a wide range of game. It's also important to consider factors like recoil and accuracy when choosing a caliber, as they can affect your ability to make a clean shot. Thanks for sharing your advice!