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Jerry Jones reported that he had a fatal cancer diagnosis several years ago, with tumors in his lymph nodes and he took an experimental drug called PT1, which cured him of his cancer.
Here is a summary.
PT1 is a small-molecule activator of AMPK (AMP-activated protein kinase). AMPK is a key energy sensor in cells that regulates cellular metabolism, especially under stress conditions like nutrient deprivation or hypoxia—common features in tumors.
Mechanism of Action in Cancer
* Activation of AMPK:
* PT1 directly binds to and activates AMPK.
* Activation of AMPK can inhibit mTOR (mammalian target of rapamycin), a pro-growth pathway often upregulated in cancer cells.
* Inhibition of mTOR Signaling: mTOR is involved in cell growth and survival. Its inhibition suppresses tumor growth and proliferation.
* Induction of Autophagy:
* AMPK activation can lead to autophagy (cellular self-digestion), which can be either pro-survival or pro-death depending on context.
* In cancer therapy, autophagy can limit cancer cell survival under stress.
* Modulation of Cellular Metabolism: PT1 may shift cancer cell metabolism from anabolic (growth-promoting) to catabolic (energy-conserving), reducing cancer cell proliferation.
* Possible Pro-apoptotic Effects: By altering survival signaling, PT1 may sensitize cancer cells to apoptosis (programmed cell death).
Natural AMPK Activation Strategy
🥼 1. Core Supplement Stack
* Berberine, 500 mg, 2× daily (before meals). Avoid taking it with other medications (can affect absorption/metabolism). Mimics metformin.
* EGCG (Green Tea Extract), 300–400 mg, 1× daily (with or without food). Use decaffeinated if sensitive. Avoid combining with iron-rich meals.
* Resveratrol (Trans-resveratrol), 150–250 mg, 1× daily (with fat-containing meal). Enhances SIRT1 and AMPK; low bioavailability, so take with fat or liposomal form.
* Quercetin, 500 mg, 1× daily (with food). Helps with inflammation and oxidative stress. Consider stacking with vitamin C for absorption.
Cycle supplements every few weeks to avoid tolerance and support long-term effectiveness.
🥗 2. AMPK-Boosting Diet
✅ Emphasize:
* Low-glycemic, anti-inflammatory foods
* Fasting-mimicking patterns
* Colorful vegetables (polyphenols: quercetin, sulforaphane, curcumin)
* Healthy fats (avocados, olive oil, nuts)
* Fermented foods (gut–immune–cancer axis)
🚫 Limit:
* Refined carbs & sugar
* Processed meats and trans fats
* Constant snacking (disrupts AMPK cycles)
⏳ 3. Intermittent Fasting (IF) or Time-Restricted Eating (TRE)
* 16:8, Fast 16 hrs, eat during 8-hour window (e.g., 12pm–8pm). Boosts AMPK, lowers insulin, improves autophagy
* 5:2, Eat normally 5 days, restrict calories 2 days/week. Activates AMPK, reduces inflammation
* 24-hr fast, Once per week/month (under supervision). Deep autophagy and AMPK activation
* 💡 Even skipping breakfast and eating from 12–8pm can help.
🏃♀️ 4. Exercise to Activate AMPK
AMPK is highly sensitive to energy stress—exercise is one of the best natural activators.
* High-intensity interval training (HIIT) – short bursts of intense effort
* Resistance training – depletes glycogen, increases AMPK
* Zone 2 cardio – enhances mitochondrial health (brisk walking, cycling)
* 🧠 Bonus: Physical activity improves immune surveillance against tumor cells.
😴 5. Sleep, Stress, and Recovery
Chronic stress and poor sleep impair AMPK signaling.
* Prioritize 7–9 hours of quality sleep
* Reduce chronic cortisol levels (meditation, breathwork, nature walks)
* Consider magnesium, ashwagandha, or L-theanine if stress/sleep is a problem
Maybe nostr:npub180cvv07tjdrrgpa0j7j7tmnyl2yr6yr7l8j4s3evf6u64th6gkwsyjh6w6 can expand his How Nostr Works series to include a page on portability