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"Neuroprotective properties
A unique feature of methylene blue is its ability to penetrate the blood-brain barrier and accumulate in the brain, which has led researchers to investigate the potential utility of this agent for the treatment of neurological disorders. In addition to its bioavailability in the brain, methylene blue also reduces oxidative stress in the brain. This chemical process is implicated in Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. More specifically, methylene blue acts as an electron carrier in the electron transport chain, wherein it inhibits complexes I and III to promote respiration.
The neuroprotective effects of methylene blue may also be attributed to its role in increasing the expression of nuclear factor erythroid 2-related factor 2 (Nrf2). Nrf2 is a transcription factor that regulates several enzymes involved in cellular stress responses, some of which include superoxide dismutase catalase, glutathione peroxidase, and glutathione reductase5. Other mechanisms by which methylene blue may induce neuroprotective effects include facilitating the degradation and clearance of tau proteins, which is a characteristic feature of Alzheimer’s disease, promoting autophagy, and reducing amyloid plaque accumulation.
To date, several randomized clinical trials (RCTs) have investigated the potential benefits of methylene blue administration in the treatment of Alzheimer’s disease. For example, one recent study reported that patients administered leuco-methylthioninium bis-hydromethanesulfonate (LMTM), a modified version of methylene blue, exhibited enhanced cognitive performance and reduced beta-amyloid plaque buildup7. Despite these observations, additional research is needed to chemically modify methylene blue to improve its uptake into the brain and include larger and more diverse patient populations."
https://www.news-medical.net/health/Potential-Health-Benefits-of-Methylene-Blue.aspx
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