Penrose, Emperor's New Mind

"We do not understand the physics that must operate at the cores of black holes nor at the big-bang origin of the universe itself. Yet all these issues seem as remote as one could imagine from the 'everyday' scale (or a little smaller) that is relevant to the workings of a human brain. And remote they certainly are! Nevertheless, I shall argue that there is another vast unknown in our physical understanding at just such a level as could indeed be relevant to the operation of human thought and consciousness-in front of (or rather behind) our very noses! It is an unknown that is not even recognized by the majority of physicists, as I shall try to explain. I shall further argue that, quite remarkably, the black holes and big bang are considerations which actually do have a definite bearing on these issues! (Penrose)"