Researchers looked at millions of women and found that 5+yr use of Depo‑Provera correlated with a 2-3x higher chance (i.e. 200% -300% risk increase) of getting a meningioma (usually benign fyi).
About 5 in 100,000 would normally get it in a year, so long‑term Depo use might raise that to around 15 in 100,000
relative risk goes up, but the absolute risk stays low
most women will never get this tumor
risk mainly matters for very long use
this isn't the only risk associated with the shot
everyone dies
