I still jump between a number of clients as they all have their strengths and weaknesses. I am primarily a desktop user so I spend most of my time on Iris but switch between snort, primal and coracle as well. I love that Iris shows likes but like that Primal shows new follows so I can more easily follow people back.
Writing a relay helped me to learn that despite there being a spec for how to communicate, many clients and relays take different approaches to solve the same issues. Love seeing the trade offs in all of them and how quickly they are learning and adapting to how users actually use the product.