There were angels back in the day of Noah who thought it might be fun to experiment with trans-humanism. God didn’t take kindly to it. Those angels are now chained in “the pit,” which as I understand it, is a particularly unappealing section of hell/hades.
The Bible tells us that knowledge will increase in the last days and, frighteningly, there will be similarities to the days of Noah. A couple of decades back, popular prophesy teachers speculated that this was a reference to some sort of human cloning or unnatural genetic modifications. That’s certainly still a possibility. Trans-humanism even more so.