How do I query a relay for multiple event IDs that are replaceable?

I need to query 50+ pairs (pubkey1, appid1), (pubkey2, appid2)... (pubkey50, appid50) for a fixed kind.

Do I need to make 50+ separate requests? One request with 50+ filters?

Or should we make {ids: ...} recognize replaceable IDs in relays?

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