I've used em before.. It was ok, I haven't tried the new pro audio.. the low latency is only really needed if you're doing record+monitor playing live instruments. I need to bench my new pipewire setup and see how many ms delay it is with realtime jams ..

Are you already doing Wayland+pipewire? It could help cause it may just be you're emulating a lot of stuff you don't need to

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I just realized I had three different audio systems installed. Jackd, pulseaudio and asla. I wonder if that can be part of my problems.

I'm thinking it's time for a clean slate install. I've been using PopOS for a couple years and I've done a lot of experimenting on it. I'm wondering if just reverting back to Debian would be a good idea at this point and kind of start from scratch.

jack2 for audio

pipewire is ok but if it's about audio, jack2

as far as low latency kernels, i'm not sure, if it was 5 or 6 kernel but i feel pretty sure that in 5 they created a realtime priority option for processes and jack/jack2/etc all started using it to make sure that audio buffers (and video) were filled before any compute was done

what is more likely to cause you issues is pulseaudio or pipewire

neither of those are tuned for minimal latency, and having an aggressively preemptive kernel isn't gonna change that, if anything, more likely result in buffers not being filled before they are dumped on the audio device