jack2 for audio
pipewire is ok but if it's about audio, jack2
as far as low latency kernels, i'm not sure, if it was 5 or 6 kernel but i feel pretty sure that in 5 they created a realtime priority option for processes and jack/jack2/etc all started using it to make sure that audio buffers (and video) were filled before any compute was done
what is more likely to cause you issues is pulseaudio or pipewire
neither of those are tuned for minimal latency, and having an aggressively preemptive kernel isn't gonna change that, if anything, more likely result in buffers not being filled before they are dumped on the audio device