I know little of the specifics myself (not a historian) so I ask these types of questions to hear new interpretations.
From what I have read, it originated from China and slowly worked its way towards Europe. The Europeans were well aware of its approach since they were receiving news on what regions it passed through. The fear made everyone mad, before, during, and after. Some of the peasantry danced in streets littered with bodies.
The Monarchies had little left to threaten them with.
I hadn't heard of the Great London Fire yet. I'll look into it. Thanks!