POMC gene is ancient, at least 500 million years old.

It is a key total-body regulatory system regulating an incredibly diverse set of bodily functions.

It’s key cleavage products include

- adrenocorticotropic hormone (ACTH)

- alpha melanocyte stimulating hormone (a-MSH)

- beta lipotropin

- beta endorphin

As well as b-MSH, y-MSH & CLIP