Leptin resistance = weight loss resistance
Disordered circadian light signals and insulation from ambient temperature cues is a shortcut to leptin resistance
Discussion
POMC gene is ancient, at least 500 million years old.
It is a key total-body regulatory system regulating an incredibly diverse set of bodily functions.
It’s key cleavage products include
- adrenocorticotropic hormone (ACTH)
- alpha melanocyte stimulating hormone (a-MSH)
- beta lipotropin
- beta endorphin
As well as b-MSH, y-MSH & CLIP
Melanocortin receptor mutations underly key human monogenic obesity disorders
